Monitoring with Optical Spectroscopy the Interactions of Hemoglobin with Nanomaterials: Post 2

So far this semester, we have had several runs of the hemoglobin with the different nanomaterials. We mainly had the results from the spectrofluorometer and UV-vis done in the lab while the CD (circular dichroism) was done at a different lab by my faculty mentor. Those results always took another week just because of the time needed to access the lab.

The data so far has shown interesting trends. There is a particular peak for hemoglobin that indicates the heme ring. This is important, because in the blood, this is where iron binds and gives blood that red color due to its interaction with oxygen. The iron binds the oxygen and transports around the body. In our results, particularly with aluminum oxide, the peak indicating the heme ring disappears.

Looking at this data, I believe that the disappearance of the heme ring could show that the aluminum oxide is binding to the heme ring. This is interesting and brings up the question, can aluminum work as a substitution for iron? And, how can we use this in terms of drug delivery? (If that even is possible.) Over break, my mentor has given me literary research to look over to help develop a possible poster, and paper.

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